It's very much depends on what kind of sensors you plan to have. 5k WMI sensors can bring down ANY machine. Not PRTG fault tho. 5k SNMP traffic? Another story. I think any modern Xeon will handle it CPU wise, but your RAM requirements entirely depends on your graph settings (configurable), and disk space of course is dictated by how much of a historic data you want. If you have access to some kind of virtualization platform, i suggest finding out the requirements by trial and error. Be advised that real monitoring system deployments can (and probably will) have "hidden" factors like security policy or some device being behind some old router, that can't handle the PPS (real story btw...) etc.
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