I have made sure the local firewall is not interfering with 443 traffic. If I start the prtg server service using port 80 I am able to get to the start page. However when I choose to use 443 for SSL the service restarts with out issue but the page is not available. Running a netstat on the prtg probe does not show that 443 is a listening port either.
Definitely need SSL as this will be integrated with AD.