This sounds like the probe is having an issue handling the amount of WMI sensors that you have on the system. If you look in the probe logs you should be able to see what sensors specifically are timing out but most likely changing the scanning intervals on some of these sensors would solve the issue.
If you need to keep them on this interval, you could also consider deploying a remote probe These will help to load balance the WMI requests. This issue isn't really a resource problem in the traditional sense of RAM and CPU, it's more an issue with the WMI subsystem limitations on the server.
Another option with this in mind would be to change some of these sensors to only use Performance Counters in the windows compatibility options of the devices or group or to switch to another monitoring protocol like SNMP.
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