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For security reasons, Microsoft recommends to disable NTLM and to use kerberos instead. If NTLM (v1 and v2) is disabled, WMI-sensors will fail because kerberos authentication is not supported.
Details of user story
NTLM is used as vector in recent malware attacks. Microsoft recomends to disable it. If NTLM is disabled via GPO it is possible to restrict NTLM for distinct servers. But as every PRTG-monitored device acts as server when WMI is used, this will not help. It makes no sense do disable NTLM domain wide and make an excaption for all domain computers. At the end, a proper use of PRTG in a Windows domain environment is incompatible with disabled NTLM.
WMI Sensors will work in a kerberos/active directory environment if NTLM v1 and NTLM v2 is disabled.